Technology Process of 1-benzyl-6,7-dimethoxy-1,3,4,5-tetrahydropyrrolo<4,3,2-de>quinolin-4-one
There total 14 articles about 1-benzyl-6,7-dimethoxy-1,3,4,5-tetrahydropyrrolo<4,3,2-de>quinolin-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 14 steps
1: iron dust, 12 M HCl / methanol / 10 h / Heating
2: Na2CO3 / diethyl ether; H2O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h
3: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h
4: tetrahydrofuran / 2 h / Ambient temperature
5: 2 M aq. NaN3 / tetrahydrofuran; H2O / 2 h / Ambient temperature
6: toluene / 0.5 h / Heating
7: toluene / 2 h / 60 °C
8: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h
9: acetonitrile / 1 h
10: NaBH3CN / acetonitrile / 12 h / 50 °C
11: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating
12: 75 percent / 1 M nBu4NF / tetrahydrofuran / 5 h / Ambient temperature
13: 5 M KOH / methanol / 3 h / Ambient temperature
14: DCC / tetrahydrofuran / Ambient temperature
With
hydrogenchloride; potassium hydroxide; sodium azide; jones reagent; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; iron; sodium cyanoborohydride; sodium carbonate; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1
- Guidance literature:
-
Multi-step reaction with 13 steps
1: Na2CO3 / diethyl ether; H2O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h
2: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h
3: tetrahydrofuran / 2 h / Ambient temperature
4: 2 M aq. NaN3 / tetrahydrofuran; H2O / 2 h / Ambient temperature
5: toluene / 0.5 h / Heating
6: toluene / 2 h / 60 °C
7: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h
8: acetonitrile / 1 h
9: NaBH3CN / acetonitrile / 12 h / 50 °C
10: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating
11: 75 percent / 1 M nBu4NF / tetrahydrofuran / 5 h / Ambient temperature
12: 5 M KOH / methanol / 3 h / Ambient temperature
13: DCC / tetrahydrofuran / Ambient temperature
With
potassium hydroxide; sodium azide; jones reagent; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; sodium carbonate; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h
2: tetrahydrofuran / 2 h / Ambient temperature
3: 2 M aq. NaN3 / tetrahydrofuran; H2O / 2 h / Ambient temperature
4: toluene / 0.5 h / Heating
5: toluene / 2 h / 60 °C
6: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h
7: acetonitrile / 1 h
8: NaBH3CN / acetonitrile / 12 h / 50 °C
9: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating
10: 75 percent / 1 M nBu4NF / tetrahydrofuran / 5 h / Ambient temperature
11: 5 M KOH / methanol / 3 h / Ambient temperature
12: DCC / tetrahydrofuran / Ambient temperature
With
potassium hydroxide; sodium azide; jones reagent; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1
