Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

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Chemical Name:Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester
CAS No.:132055-14-2
Molecular Formula:C₄₃H₄₃N₅O₁₀
Molecular Weight:789.842
Hs Code.:

Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

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Chemical Property of Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

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Technology Process of Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

There total 1 articles about Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 81352-26-3
5'-dimethoxytrityl-N-benzoylguanosine

: 132055-14-2
Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

: Carbonic acid (2R,3S,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

: Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-tert-butoxycarbonyloxy-tetrahydro-furan-3-yl ester tert-butyl ester

Guidance literature:: With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1) DMF, -5 deg C, 1 h, 2) DMF, -10 deg C, 4 h;
DOI:10.1055/s-1990-27087

Reference yield:

: 132055-14-2
Carbonic acid (2R,3R,4R,5R)-2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester tert-butyl ester

: Carbonic acid 2-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(4-chloro-phenoxy)-hydroxy-phosphoryloxy]-tetrahydro-furan-3-yl ester tert-butyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methylimidazole / dioxane / 3 h / Ambient temperature

2: aq. pyridine / 2 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; In 1,4-dioxane;
DOI:10.1002/prac.19943360308