69507-62-6

Upstream product

• 109-78-4 3-Hydroxypropionitrile 
• 772-79-2 4-chlorophenylphosphorodichloridate 

Downstream Products

• 71100-72-6 5'-O-(dimethoxytrityl)-N-isobutyrylguanine 3'-(p-chlorophenylcyanoethyl phosphate) 
• 57777-87-4 N⁴-benzoyl-5'-O-(p,p'-dimethoxytrityl)deoxycytidine 3'-<(p-chlorophenyl)(β-cyanoethyl)phosphate> 
• 57777-86-3 5'-O-(dimethoxytrityl)-N-benzoyladenine 3'-(p-chlorophenylcyanoethyl phosphate) 
• 57777-78-3 thymidine-3'-p-chlorophenyl-β-cyanoethyl-phosphate 
• 71002-59-0 N²-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester 
• 81551-80-6 C₄₃H₄₇Cl₂N₁₁O₁₅P₂ 
• 99678-41-8 Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 4-chloro-phenyl ester 
• 71459-47-7 dbzC<*>dbzAp(ClPh,CNEt) 
• 74930-93-1 C₄₅H₄₅Cl₂N₉O₁₅P₂ 
• 90827-16-0 C₃₉H₄₂Cl₂N₈O₁₅P₂ 
• 67221-67-4 C₄₁H₄₀Cl₂N₆O₁₅P₂ 
• 72952-22-8 Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(4-chloro-phenoxy)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 67473-53-4 dbzCp(ClPh,CNEt) 
• 69924-11-4 C₆₄H₆₅Cl₂N₁₁O₁₇P₂ 

Relevant academic research and scientific papers

The tert-Butyloxycarbonyl-(Boc) Group, a Suitable 2'-OH-Protecting Group in Oligoribonucleotide Solid-Phase Synthesis

The solid-phase synthesis of the dodecaribonucleotide ACCACUAAAGCG is described using the tert-butyloxycarbonyl (Boc) as 2'-OH-protecting group.The synthesis was carried out on a filter disc support Whatman 3 MM by the phosphotriester method.Under these c

An alternative base-pairing of catechol-bearing nucleosides by borate formation

A chelator-type β-C-nucteoside having a catechol ligand as the nucleobase was found to form a stable 2 : 1 complex with trimethyl borate, which was characterized by 1H-NMR and etectrospray ionization time-of-flight (ESI-TOF) mass speetroseopies

Nucleosidic phosphorylating agent and methods

Compounds of the formula STR1 where R is a base labile substituted-phenyloxy protecting group, are useful as phosphorylating reagents in the synthesis of oligonucleotides by a phosphotriester method. Such compounds are made by the reaction of β-cyanoethan

Nucleosides and Nucleotides. Part 17. A Simple Preparation of Protected Deoxynucleoside-3'-phosphates

A simple method for the preparation of fully protected 2'-deoxynucleoside-3'-phosphates is described.The main step, phosphorylation of partially protected deoxynucleosides, is performed with the monofunctional reagent p-chlorophenyl(2-cyanoethyl)phosphochloridate (2) in dioxane.This reagent is quickly prepared from readily accessible p-chlorophenyl phosphodichloridate by reaction with 3-hydroxypropionitrile and triethylamine in dioxane or ether.The crude reagent is used directly for phosphorylation.After chromatography, protected deoxynucleoside-3'-phosphonates were isolated in yields of 80-87percent .The method described here, which has been optimized in detail, represents a simple alternative to published methods.