Technology Process of Cbz-Phe-Aib4-GlyNH2
There total 5 articles about Cbz-Phe-Aib4-GlyNH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/anie.201107583
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3 h / 120 °C / Inert atmosphere
2: triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere
4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201107583
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane;
DOI:10.1002/anie.201107583
