Technology Process of S-phenyl (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate
There total 5 articles about S-phenyl (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: phosphorus pentoxide / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / 95 °C / Inert atmosphere
3: sodium hydride / N,N-dimethyl-formamide / 0 °C
4: potassium fluoride; palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 170 °C / Microwave irradiation
5: sodium hydroxide / water; N,N-dimethyl-formamide
6: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 6 h / Cooling with ice
With
dmap; potassium fluoride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phosphorus pentoxide; palladium diacetate; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200867
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / 95 °C / Inert atmosphere
2: sodium hydride / N,N-dimethyl-formamide / 0 °C
3: potassium fluoride; palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 170 °C / Microwave irradiation
4: sodium hydroxide / water; N,N-dimethyl-formamide
5: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 6 h / Cooling with ice
With
dmap; potassium fluoride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium diacetate; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200867
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / water; N,N-dimethyl-formamide
2: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 6 h / Cooling with ice
With
dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide;
In
water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200867
