((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate

Base Information

Chemical Name:((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate
CAS No.:1395786-55-6
Molecular Formula:C₂₄H₂₈O₇*H₂O
Molecular Weight:446.497
Hs Code.:

((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate

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Chemical Property of ((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate

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Technology Process of ((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate

There total 2 articles about ((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 903565-83-3
(1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′,6′-tetrahydro-6′-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2′-[2H]pyran]-3′,4′,5′-triol

: 75-36-5
acetyl chloride

: 1395786-55-6
((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate

Guidance literature:: With 2,4,6-trimethyl-pyridine; at -10 - 20 ℃;
DOI:10.1021/jm300884k

Reference yield:

: 903566-44-9
(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6′-((benzyloxy)-methyl)-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6-carbaldehyde

: 1395786-55-6
((1S,3′R,4′S,5′S,6′R)-6-[(4-ethylphenyl)methyl]-3′,4′,5′-trihydroxy-3′,4′,5′,6′-tetrahydro-3H-spiro[2-benzofuran-1,2′-pyran]-6′-yl)methyl acetate hydrate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 0 - 20 °C

2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.25 h / -40 °C

3: palladium(II) hydroxide; hydrogenchloride; hydrogen / methanol; ethyl acetate / 0.75 h / 20 °C

4: 2,4,6-trimethyl-pyridine / -10 - 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; triethylsilane; boron trifluoride diethyl etherate; hydrogen; palladium(II) hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm300884k