[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 125423-98-5
• Molecular Formula: C₂₂H₃₇NO₃
• Molecular Weight: 363.541
• Mol file: 125423-98-5.mol

Synonyms:

Chemical Property of [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

There total 4 articles about [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1S,3S,4R)-menthyl glycinate (120143-37-5) + (1S,2S,5S)-(-)-2-hydroxypinan-3-one (1845-25-6) → [(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (125423-98-5,125473-87-2,125473-88-3,125473-89-4)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; for 36h; Heating;

Reference yield: 90.0%

(1S,3S,4R)-menthyl glycinate (120143-37-5) + (-)-(2R,3R,5R)-2-hydroxy-3-pinanone (1845-25-6,10136-65-9,20536-50-9,73466-08-7,84236-04-4,125073-44-1,24047-72-1) → [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (125423-98-5,125473-87-2,125473-88-3,125473-89-4)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; for 36h; Heating;

Reference yield: 85.0%

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-aminoacetate (63254-60-4,80655-94-3,120143-37-5) + (-)-(2R,3R,5R)-2-hydroxy-3-pinanone (1845-25-6,10136-65-9,20536-50-9,73466-08-7,84236-04-4,125073-44-1,24047-72-1) → [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (125423-98-5,125473-87-2,125473-88-3,125473-89-4)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; for 36h; Heating;

upstream raw materials:

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-aminoacetate

(1S,2S,5S)-(-)-2-hydroxypinan-3-one

(1S,3S,4R)-menthyl glycinate

(-)-(2R,3R,5R)-2-hydroxy-3-pinanone

Downstream raw materials:

2-[(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

2-[(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

D-Val-OH

L-valine