2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: 2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 125424-02-4
• Molecular Formula: C₂₅H₄₁NO₃
• Molecular Weight: 403.605
• Mol file: 125424-02-4.mol

Synonyms:

Chemical Property of 2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

There total 12 articles about 2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

allyl bromide (106-95-6) + [(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (125423-98-5,125473-87-2,125473-88-3,125473-89-4) → 2-[(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (125424-02-4,125473-91-8,125473-92-9,125473-93-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -50 ℃; for 5h;

Reference yield: 82.0%

allyl bromide (106-95-6) + [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (125423-98-5,125473-87-2,125473-88-3,125473-89-4) → 2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (125424-02-4,125473-91-8,125473-92-9,125473-93-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -50 ℃; for 5h;

Reference yield: 71.0%

allyl bromide (106-95-6) + [(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (125423-98-5,125473-87-2,125473-88-3,125473-89-4) → 2-[(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-pent-4-enoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (125424-02-4,125473-91-8,125473-92-9,125473-93-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -50 ℃; for 5h;

upstream raw materials:

allyl bromide

[(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-aminoacetate

(1S,2S,5S)-(-)-2-hydroxypinan-3-one

Downstream raw materials:

D-allylglycine

L-allylglycine