(1S,3R)-3-nitromethylcyclohexanol

Base Information

• Chemical Name: (1S,3R)-3-nitromethylcyclohexanol
• CAS No.: 196790-44-0
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Mol file: 196790-44-0.mol

Synonyms:

Chemical Property of (1S,3R)-3-nitromethylcyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R)-3-nitromethylcyclohexanol

There total 4 articles about (1S,3R)-3-nitromethylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-(nitromethyl)cyclohexanone (50870-56-9) → (1S,3S)-3-(nitromethyl)cyclohexanol + (1S,3R)-3-nitromethylcyclohexanol (196790-44-0)

Guidance literature:

With baker's yeast; Sucrose; at 30 ℃; for 96h;

DOI:10.1016/S0957-4166(97)00370-4

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 3-Nitromethyl-cyclohexanol → (1S,3R)-3-nitromethylcyclohexanol (196790-44-0) + (1R,3R)-3-nitromethylcyclohexanol + Acetic acid (1R,3S)-3-nitromethyl-cyclohexyl ester

Guidance literature:

With 4 A molecular sieve; Lipase PS (Amano); In benzene; at 30 ℃; for 4.5h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(97)10705-5

Reference yield:

cyclohexenone (930-68-7) → (1S,3R)-3-nitromethylcyclohexanol (196790-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: proline Rb salt / CHCl₃

2: NaBH₄ / ethanol / 6 h / Ambient temperature

With sodium tetrahydroborate; proline rubidium salt; In ethanol; chloroform;

DOI:10.1016/S0957-4166(97)00370-4

upstream raw materials:

3-(nitromethyl)cyclohexanone

(+)-(R)-3-(nitromethyl)cyclohexan-1-one

vinyl acetate

cyclohexenone