Technology Process of (R)-2-((3,3-dimethyloxiran-2-yl)methyl)-3,6-dimethoxyphenol
There total 4 articles about (R)-2-((3,3-dimethyloxiran-2-yl)methyl)-3,6-dimethoxyphenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(5S,8R,9R)-2,2-dimethyl-10-oxo-1,3,6-trioxaspiro[4.5]decane-8,9-diyl diacetate; Oxone; potassium carbonate; tetrabutylammonium sulfate;
In
acetonitrile;
at 0 ℃;
for 22h;
Overall yield = 95 %;
DOI:10.1039/c3ob41497c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(II) choride dihydrate / acetonitrile / 0.25 h / 0 °C
1.2: 7 h / 0 - 38 °C
2.1: hydrogen; 5% palladium on barium sulphate; quinoline / ethyl acetate / 0.67 h / 760.05 Torr
3.1: N,N-dimethyl-formamide / 5 h / 120 °C
4.1: potassium carbonate; (5S,8R,9R)-2,2-dimethyl-10-oxo-1,3,6-trioxaspiro[4.5]decane-8,9-diyl diacetate; Oxone; tetrabutylammonium sulfate / acetonitrile / 22 h / 0 °C
With
(5S,8R,9R)-2,2-dimethyl-10-oxo-1,3,6-trioxaspiro[4.5]decane-8,9-diyl diacetate; quinoline; Oxone; copper(II) choride dihydrate; 5% palladium on barium sulphate; hydrogen; potassium carbonate; tetrabutylammonium sulfate;
In
ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
3.1: |Claisen Rearrangement;
DOI:10.1039/c3ob41497c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen; 5% palladium on barium sulphate; quinoline / ethyl acetate / 0.67 h / 760.05 Torr
2: N,N-dimethyl-formamide / 5 h / 120 °C
3: potassium carbonate; (5S,8R,9R)-2,2-dimethyl-10-oxo-1,3,6-trioxaspiro[4.5]decane-8,9-diyl diacetate; Oxone; tetrabutylammonium sulfate / acetonitrile / 22 h / 0 °C
With
(5S,8R,9R)-2,2-dimethyl-10-oxo-1,3,6-trioxaspiro[4.5]decane-8,9-diyl diacetate; quinoline; Oxone; 5% palladium on barium sulphate; hydrogen; potassium carbonate; tetrabutylammonium sulfate;
In
ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
2: |Claisen Rearrangement;
DOI:10.1039/c3ob41497c
