3-BroMo-1,1-difluoro-cycl...

Base Information

• Chemical Name: 3-BroMo-1,1-difluoro-cycl...
• CAS No.: 1310729-91-9
• Molecular Formula: C₄H₅BrF₂
• Molecular Weight: 170.985
• Hs Code.: 2903898090
• Mol file: 1310729-91-9.mol

Synonyms:

Chemical Property of 3-BroMo-1,1-difluoro-cycl...

Chemical Property:

• Boiling Point: 113.4±40.0 °C(Predicted)
• Density: 1.69±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-1,1-difluorocyclobutane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-BroMo-1,1-difluoro-cycl...

There total 1 articles about 3-BroMo-1,1-difluoro-cycl... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3,3-difluorocyclobutanecarboxylic acid (107496-54-8) → 1-bromo-3,3-difluorocyclobutane (1310729-91-9)

Guidance literature:

3,3-difluorocyclobutanecarboxylic acid; With mercury(II) oxide; In dichloromethane; for 0.333333h; Inert atmosphere; Reflux;

With bromine; In dichloromethane; for 6.15h; Inert atmosphere; Reflux;

DOI:10.1055/s-0037-1610237

Reference yield: 44.0%

5-(4'-bromophenyl)-2-pyridinecarbonitrile (951657-98-0) + 1-bromo-3,3-difluorocyclobutane (1310729-91-9) → 5-(4-(3,3-difluorocyclobutyl)phenyl)picolinonitrile

Guidance literature:

With 2,4,6-trimethyl-pyridine; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine]nickel(II) dichloride; tris-(trimethylsilyl)silane; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In 1,2-dimethoxyethane; at 32 ℃; Reagent/catalyst; Solvent; Sonication; Irradiation;

DOI:10.1021/acs.joc.1c02013

upstream raw materials:

3,3-difluorocyclobutanecarboxylic acid