(2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

Base Information

Chemical Name:(2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol
CAS No.:336128-33-7
Molecular Formula:C₆₇H₈₉FO₇SSi₂
Molecular Weight:1113.67
Hs Code.:

(2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

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Chemical Property of (2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

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Technology Process of (2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

There total 7 articles about (2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20808-12-2
fluoromethyl phenyl sulfone

: 336128-31-5
10-oxo-19-nor-1α,25-dihydroxyvitamin D₃ 1,3-di-tert-butyldiphenylsilyl-25-methoxymethyl ether

: 336128-33-7
(2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

Guidance literature:: fluoromethyl phenyl sulfone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

10-oxo-19-nor-1α,25-dihydroxyvitamin D₃ 1,3-di-tert-butyldiphenylsilyl-25-methoxymethyl ether; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1248/cpb.49.312

Reference yield:

: 214351-87-8
(3-Methoxymethoxy-3-methyl-butane-1-sulfonyl)-benzene

: 336128-33-7
(2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 0.33 h / -20 °C

1.2: 83 percent / HMPA / tetrahydrofuran / 2 h / -20 °C

2.1: 65 percent / 10 percent Na-Hg; MeOH / tetrahydrofuran / 0 °C

3.1: 94 percent / phenyl isocyanate; Et₃N / toluene / 16 h / 20 °C

4.1: aq. Mo(CO)6 / acetonitrile / 17 h / Heating

5.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: tetrahydrofuran / 2 h / -78 °C

With methanol; sodium amalgam; hexacarbonyl molybdenum; phenyl isocyanate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene; acetonitrile;
DOI:10.1248/cpb.49.312

Reference yield:

: 162636-76-2
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

: 336128-33-7
(2S,4R)-1-(Benzenesulfonyl-fluoro-methyl)-2,4-bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 0.33 h / -20 °C

1.2: 83 percent / HMPA / tetrahydrofuran / 2 h / -20 °C

2.1: 65 percent / 10 percent Na-Hg; MeOH / tetrahydrofuran / 0 °C

3.1: 94 percent / phenyl isocyanate; Et₃N / toluene / 16 h / 20 °C

4.1: aq. Mo(CO)6 / acetonitrile / 17 h / Heating

5.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: tetrahydrofuran / 2 h / -78 °C

With methanol; sodium amalgam; hexacarbonyl molybdenum; phenyl isocyanate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene; acetonitrile;
DOI:10.1248/cpb.49.312