C₅₅H₆₄N₆O₂₀P₂

Base Information

• Chemical Name: C₅₅H₆₄N₆O₂₀P₂
• CAS No.: 264885-99-6
• Molecular Formula: C₅₅H₆₄N₆O₂₀P₂
• Molecular Weight: 1191.09
• Mol file: 264885-99-6.mol

Synonyms:

Chemical Property of C₅₅H₆₄N₆O₂₀P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₆₄N₆O₂₀P₂

There total 3 articles about C₅₅H₆₄N₆O₂₀P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-O-acetylthymidine (21090-30-2) → C55H64N6O20P2 (264885-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: DBU; LiCl

2: 3 percent trichloroacetic acid / CH₂Cl₂

3: DBU; LiCl

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichloroacetic acid; In dichloromethane; 1: Condensation / 2: Substitution / 3: Condensation;

DOI:10.1021/ol991376o

Reference yield:

(SP)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate (90865-76-2) → C55H64N6O20P2 (264885-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 percent trichloroacetic acid / CH₂Cl₂

2: DBU; LiCl

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichloroacetic acid; In dichloromethane; 1: Substitution / 2: Condensation;

DOI:10.1021/ol991376o

Reference yield:

(S)-Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester (129395-81-9) → C55H64N6O20P2 (264885-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: DBU; LiCl

2: 3 percent trichloroacetic acid / CH₂Cl₂

3: DBU; LiCl

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichloroacetic acid; In dichloromethane; 1: Condensation / 2: Substitution / 3: Condensation;

DOI:10.1021/ol991376o

upstream raw materials:

3'-O-acetylthymidine

(S_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate

(S)-Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester