tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

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Chemical Name:tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate
CAS No.:1369959-24-9
Molecular Formula:C₃₀H₂₈Cl₂F₄N₄O₃
Molecular Weight:639.477
Hs Code.:

tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

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Chemical Property of tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

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Technology Process of tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

There total 4 articles about tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 298690-90-1
(S)-2-(4-fluorophenyl)pyrrolidine

: 1197001-77-6
4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-5-methyl-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid

: 1369959-24-9
tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-17-0
methyl 7-(3,4-dichlorophenyl)-5-methyl-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

: 1369959-24-9
tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-16-9
4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

: 1369959-24-9
tert-butyl 7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)-pyrrolidine-1-carbonyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201386u