8-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Base Information

Chemical Name:8-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one
CAS No.:33449-59-1
Molecular Formula:C₁₁H₁₆O
Molecular Weight:164.247
Hs Code.:
DSSTox Substance ID:DTXSID401224944
Nikkaji Number:J443.965A

Synonyms:33449-59-1;DTXSID401224944;4,4a,5,6,7,8-Hexahydro-8-methyl-2(3H)-naphthalenone

Suppliers and Price of 8-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:164.120115130
Heavy Atom Count:12
Complexity:227

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCCC2C1=CC(=O)CC2

Technology Process of 8-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

There total 3 articles about 8-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91306-30-8
(R)-(+)-2-methyl-2-(3-oxobutyl)cyclohexanone

: 63975-59-7
(R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one

: 33449-59-1
8-Methyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one

Guidance literature:: With sodium methylate; In methanol; at 60 ℃; for 10h; Inert atmosphere;
DOI:10.15227/orgsyn.070.0035

Reference yield:

: 195251-76-4
E/Z-<2(RS)>-2-Methyl-N-(S-α-methylbenzyl)-cyclohexaneimine

: 63975-59-7
(R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one

: 33449-59-1
8-Methyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 24 h / 40 °C / Inert atmosphere

2: acetic acid; water / 2 h / 20 °C

3: sodium methylate / methanol / 10 h / 60 °C / Inert atmosphere

With water; sodium methylate; acetic acid; In methanol;
DOI:10.15227/orgsyn.070.0035

Reference yield:

: 583-60-8
2-Methylcyclohexanone

: 63975-59-7
(R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one

: 33449-59-1
8-Methyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 24 h / Dean-Stark; Reflux

2: 24 h / 40 °C / Inert atmosphere

3: acetic acid; water / 2 h / 20 °C

4: sodium methylate / methanol / 10 h / 60 °C / Inert atmosphere

With water; sodium methylate; acetic acid; In methanol; toluene;
DOI:10.15227/orgsyn.070.0035