Technology Process of 3-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-butyric acid
There total 8 articles about 3-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-butyric acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1039/c3md00214d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4: lithium hydroxide; water / tetrahydrofuran / 0 - 20 °C
With
palladium 10% on activated carbon; water; hydrogen; triethylamine; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c3md00214d
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / isopropyl alcohol / 2 h / 20 °C / Inert atmosphere
2: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; lithium chloride / N,N-dimethyl-formamide / 3 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C
4: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
5: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
6: lithium hydroxide; water / tetrahydrofuran / 0 - 20 °C
With
bis(triphenylphosphine)palladium(II) dichloride; palladium 10% on activated carbon; water; hydrogen; triethylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
2: |Heck Reaction;
DOI:10.1039/c3md00214d
