C₂₆H₃₁N₃O₃Si

Base Information

• Chemical Name: C₂₆H₃₁N₃O₃Si
• CAS No.: 1345024-37-4
• Molecular Formula: C₂₆H₃₁N₃O₃Si
• Molecular Weight: 461.636
• Mol file: 1345024-37-4.mol

Synonyms:

Chemical Property of C₂₆H₃₁N₃O₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₁N₃O₃Si

There total 14 articles about C₂₆H₃₁N₃O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-((1R,4R,5R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-oxabicyclo[3.1.0]hexan-1-yl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one (1345024-34-1) → C26H31N3O3Si (1345024-37-4)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo201716c

Reference yield:

tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane (287933-72-6) → C26H31N3O3Si (1345024-37-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1.25 h / -78 - 0 °C / Inert atmosphere

1.2: 1.25 h / -78 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: diethylzinc / dichloromethane; toluene / 1 h / 0 - 20 °C / Inert atmosphere

4.1: sodium periodate; ruthenium trichloride; sodium hydrogencarbonate / chloroform; water; acetonitrile / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 0 - 20 °C / Inert atmosphere

6.1: toluene / 2 h / 80 °C / Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

7.2: 0.5 h / -78 °C / Inert atmosphere

8.1: ammonium hydroxide / ethanol; water / 5 h / 100 °C / Inert atmosphere; Sealed tube

9.1: triethylamine; trichlorophosphate / acetonitrile / 1 h / 0 °C / Inert atmosphere

9.2: 0 - 20 °C / Inert atmosphere

10.1: ammonium hydroxide / 1,4-dioxane; water / 20 °C / Inert atmosphere

With ruthenium trichloride; ammonium hydroxide; sodium periodate; n-butyllithium; diphenyl phosphoryl azide; tert.-butyl lithium; diethylzinc; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; chloroform; water; toluene; acetonitrile; pentane; 3.1: Simmons-Smith reaction / 6.1: Curtius rearrangement;

DOI:10.1021/jo201716c

Reference yield:

(2S,3R,4R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-cyanotetrahydrofuran-3-yl acetate (1345023-89-3) → C26H31N3O3Si (1345024-37-4)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 96 h / Inert atmosphere

2.1: sodium hydride / mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 - 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: diethylzinc / dichloromethane; toluene / 1 h / 0 - 20 °C / Inert atmosphere

5.1: sodium periodate; ruthenium trichloride; sodium hydrogencarbonate / chloroform; water; acetonitrile / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 0 - 20 °C / Inert atmosphere

7.1: toluene / 2 h / 80 °C / Inert atmosphere

8.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

8.2: 0.5 h / -78 °C / Inert atmosphere

9.1: ammonium hydroxide / ethanol; water / 5 h / 100 °C / Inert atmosphere; Sealed tube

10.1: triethylamine; trichlorophosphate / acetonitrile / 1 h / 0 °C / Inert atmosphere

10.2: 0 - 20 °C / Inert atmosphere

11.1: ammonium hydroxide / 1,4-dioxane; water / 20 °C / Inert atmosphere

With ruthenium trichloride; ammonium hydroxide; sodium periodate; n-butyllithium; diphenyl phosphoryl azide; diethylzinc; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; chloroform; water; toluene; acetonitrile; mineral oil; 4.1: Simmons-Smith reaction / 7.1: Curtius rearrangement;

DOI:10.1021/jo201716c

upstream raw materials:

(2S,3R,4R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-cyanotetrahydrofuran-3-yl acetate

(2S,3R,4R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-3-hydroxytetrahydrofuran-2-carbonitrile

(R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-4,5-dihydrofuran-2-carbonitrile

((1R,4R,5R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-oxabicyclo[3.1.0]hexan-1-yl)methanol