tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane

Base Information

• Chemical Name: tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane
• CAS No.: 287933-72-6
• Molecular Formula: C₂₁H₂₆O₂Si
• Molecular Weight: 338.522
• Mol file: 287933-72-6.mol

Synonyms:tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane

Chemical Property of tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane

There total 5 articles about tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran (287933-71-5) → tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane (287933-72-6)

Guidance literature:

With sodium dihydrogenphosphate; sodium amalgam; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(00)00467-6

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane (287933-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 20 h / 20 °C

2: 100 percent / NaH₂PO₄*H₂O; 5 percent sodium amalgam / methanol; tetrahydrofuran / 1 h / -30 - 5 °C

With dmap; sodium dihydrogenphosphate; sodium amalgam; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1007/s007060200024

Reference yield:

(3S)-4-phenylsulfonyl-2,3-dihydrofuran-3-methanol (287933-70-4) → tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane (287933-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 20 h / 20 °C

2: 100 percent / NaH₂PO₄*H₂O; 5 percent sodium amalgam / methanol; tetrahydrofuran / 1 h / -30 - 5 °C

With dmap; sodium dihydrogenphosphate; sodium amalgam; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1007/s007060200024

upstream raw materials:

(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

tert-butylchlorodiphenylsilane

(3S)-4-phenylsulfonyl-2,3-dihydrofuran-3-methanol

(R)-2-((E)-(2-phenylsulfonyl)-ethenyloxymethyl)-oxirane

Downstream raw materials:

C₂₅H₃₂O₆Si

C₂₆H₃₁N₃O₃Si

1-((1R,4R,5R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-oxabicyclo[3.1.0]hexan-1-yl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one

C₂₇H₃₂N₂O₄Si