diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

Base Information

Chemical Name:diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate
CAS No.:924884-94-6
Molecular Formula:C₄₅H₆₃N₃O₁₄Si
Molecular Weight:898.092
Hs Code.:

diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

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Chemical Property of diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

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Technology Process of diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

There total 8 articles about diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.4%

: 924884-98-0
diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-{2-[4-(p-nitrophenoxycarbonyl)oxybutyryl]hydrazino}carbonyloxymethylmalonate

: 154928-41-3
2-amino-1-O-(4,4'-dimethoxytrityl)propane-1,3-diol

: 924884-94-6
diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

Guidance literature:: With pyridine; dmap; In dichloromethane; for 16h;
DOI:10.1007/s11172-006-0175-5

Reference yield:

: 924884-95-7
diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-hydroxymethylmalonate

: 924884-94-6
diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / pyridine; DMAP / CH₂Cl₂ / 2.5 h

2: 66.3 percent / pyridine; DMAP / dimethylformamide / 16 h

3: 72.5 percent / pyridine; DMAP / CH₂Cl₂ / 2 h

4: 62.4 percent / pyridine; DMAP / CH₂Cl₂ / 16 h

With pyridine; dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s11172-006-0175-5

Reference yield:

: 924884-96-8
diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-(p-nitrophenoxycarbonyl)oxymethylmalonate

: 924884-94-6
diethyl 2-tert-butyl(dimethyl)silyloxymethyl-2-[2-(4-{N-[1-(4,4'-dimethoxy)trityloxy-3-hydroxypropan-2-yl]carbamoyloxy}butyryl)hydrazino]carbonyloxymethylmalonate

Guidance literature:: Multi-step reaction with 3 steps

1: 66.3 percent / pyridine; DMAP / dimethylformamide / 16 h

2: 72.5 percent / pyridine; DMAP / CH₂Cl₂ / 2 h

3: 62.4 percent / pyridine; DMAP / CH₂Cl₂ / 16 h

With pyridine; dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s11172-006-0175-5