154928-41-3Relevant academic research and scientific papers
Modified oligonucleotides and compound that can be used for synthesizing same
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Paragraph 0129-0130, (2020/12/08)
The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.
Novel Reagents Utilizing A Serinol Scaffold For Labeling Synthetic Oligonucleotides
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Page/Page column 4; 9, (2011/04/19)
Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5′ or 3′ termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.
New phosphoramidite derivatives for the preparation of oligonucleotides containing a hydrazide group in any specified position of the oligonucleotide chain
Antsypovich,Oretskaya,Von Kiedrowski
, p. 2671 - 2681 (2007/10/03)
A new versatile method for the preparation of oligonucleotides containing hy drazide groups in any position of the oligonucleotide chain by standard phosphoramidite automated oligonucleotide synthesis is proposed. The method is based on the use of a serie
Solid-phase synthesis of oligonucleotides containing a bipyridine ligand at the 3′-3′ inversion of polarity site
Galeone, Aldo,Mayol, Luciano,Oliviero, Giorgia,Rigano, Daniela,Varra, Michela
, p. 383 - 386 (2007/10/03)
The preparation of a solid support useful for the synthesis of oligonucleotides with a 3′-3′ inversion of polarity, via a linker containing a chelating molecule, namely 2,2′-bipyridine, is described.
Synthesis and hybridization properties of sugar-modified oligonucleotides
Sharma, Ashwani K.,Kumar, Pradeep,Gupta, Kailash C.
, p. 3643 - 3649 (2007/10/03)
L-Threoninol-derived acyclic nucleotide monomers were prepared and incorporated into oligonucleotides at preselected positions via phosphoramidite chemistry. Hybridization properties of these modified oligonucleotides with the corresponding natural oligom
Synthesis of modified oligonucleotides and production of duplexes with covalently linked chains
Antsypovich, Sergey I.,Oretskaya, Tatiana S.,Volkov, Evgeny M.,Romanova, Elena A.,Tashlitsky, Vadim N.,Blumenfeld, Marta,Shabarova, Zoe A.
, p. 923 - 936 (2007/10/03)
A method has been devised to synthesize a DNA-duplex with covalently connected strands. Primary amino group located on one strand is linked to a carboxyl group of the other strand through the agency of a water soluble carbodiimide condensing agent. Conditions for the reaction between chains of a duplex composed of the modified oligonucleotides [1] were optimized. The thermal and hydrolytic stability of the cross linked duplex was examined.
Synthesis of Modified Oligonucleotides and Their Duplexes with Covalently Linked Strands
Antsypovich, S. I.,Volkov, E. M.,Oretskaya, T. S.,Romanova, E. A.,Tashlitskii, V. N.,et al.
, p. 669 - 674 (2007/10/03)
A method for the synthesis of DNA duplex with covalently linked strands was elaborated, and the thermal and hydrolytic stability of the duplex was studied.The strands were connected via an amide bond between carboxyl and aliphatic amino groups in the presence of water-soluble carbodiimide.For this purpose, a series of modified 5- to 26-meric oligonucleotides with primary amino or carboxyl group were prepared, and their properties were investigated. - Key words: modified oligonucleotides; 2'-amino-2'-deoxycytidine; DNA-duplex with covalently linked strands
