bis-(p-dimethylaminophenyl)chloromethylphosphine oxide

Base Information

• Chemical Name: bis-(p-dimethylaminophenyl)chloromethylphosphine oxide
• CAS No.: 108142-52-5
• Molecular Formula: C₁₇H₂₂ClN₂OP
• Molecular Weight: 336.801
• Mol file: 108142-52-5.mol

Synonyms:

Chemical Property of bis-(p-dimethylaminophenyl)chloromethylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-(p-dimethylaminophenyl)chloromethylphosphine oxide

There total 3 articles about bis-(p-dimethylaminophenyl)chloromethylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis-(p-dimethylaminophenyl)chloromethylphosphine oxide (108142-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 27.0 g / PCl₃ / 3 h

2: 4.04 g / 50 percent KOH / dimethylsulfoxide / 1 h / 50 °C

3: 2.42 g / PCl₅ / CHCl₃ / 3 h / Heating

With potassium hydroxide; phosphorus pentachloride; phosphorus trichloride; In chloroform; dimethyl sulfoxide;

Reference yield:

sodium p-dimethylaminophenyl phosphinate → bis-(p-dimethylaminophenyl)chloromethylphosphine oxide (108142-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.04 g / 50 percent KOH / dimethylsulfoxide / 1 h / 50 °C

2: 2.42 g / PCl₅ / CHCl₃ / 3 h / Heating

With potassium hydroxide; phosphorus pentachloride; In chloroform; dimethyl sulfoxide;

Reference yield:

bis[4-(N,N-dimethylaminephenyl)]phosphine oxide (84127-06-0) → bis-(p-dimethylaminophenyl)chloromethylphosphine oxide (108142-52-5)

Guidance literature:

With phosphorus pentachloride;

upstream raw materials:

bis[4-(N,N-dimethylaminephenyl)]phosphine oxide

N,N-dimethyl-aniline

Downstream raw materials:

bis-(p-dimethylaminophenyl)-p-nitrophenoxymethylphosphine oxide

Refernces

• 1、 Yarkevich, A. N.,Tkachenko, S. E.,Tsvetkov, E. N.. "NUCLEOPHILIC SUBSTITUTION OF CHLORINE ATOM IN DIARYL CHLOROMETHYLPHOSPHINE OXIDES". . p. 1430 - 1435. Retrieved 2007/10/02.