(2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

Base Information

• Chemical Name: (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS No.: 75421-10-2
• Molecular Formula: C₃₁H₂₈N₂O₈
• Molecular Weight: 556.572
• Mol file: 75421-10-2.mol

Synonyms:

Chemical Property of (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

There total 3 articles about (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

→ (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate (75421-10-2)

Guidance literature:

Reference yield:

1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (72331-40-9) → (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate (75421-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2 h / Ambient temperature

2: HgO, HgBr₂ / benzene / 18 h / Heating

With mercury dibromide; mercury(II) oxide; In acetonitrile; benzene;

DOI:10.1021/jm00138a003

Reference yield:

1,3-di(trimethylsilyl)-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (77249-74-2) + 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide (22860-91-9) → (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate (75421-10-2)

Guidance literature:

With mercury dibromide; mercury(II) oxide; In benzene; for 18h; Yield given; Heating;

DOI:10.1021/jm00138a003

upstream raw materials:

1,3-di(trimethylsilyl)-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one

2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide

1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one

Downstream raw materials:

C₃₇H₃₄N₂O₉Se

C₃₇H₃₄N₂O₉Se

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4-dihydro-1H-1,3-diazepin-2(7H)-one

C₃₁H₂₈N₂O₉