Technology Process of (1R)-1-[(4R,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]butyl benzoate
There total 5 articles about (1R)-1-[(4R,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]butyl benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C8H16O3; benzoic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
2,2-dimethoxy-propane;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jo202199g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) isopropylate / dichloromethane / 0.25 h / Inert atmosphere
2.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 0.33 h / 0 °C / Inert atmosphere
2.3: 2 h / 0 - 20 °C / Inert atmosphere
With
titanium(IV) isopropylate;
In
dichloromethane;
1.1: Sharpless dihydroxylation;
DOI:10.1021/jo202199g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere
2.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / 18 h / -20 °C / Molecular sieve; Inert atmosphere
3.1: titanium(IV) isopropylate / dichloromethane / 0.25 h / Inert atmosphere
4.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4.2: 0.33 h / 0 °C / Inert atmosphere
4.3: 2 h / 0 - 20 °C / Inert atmosphere
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate;
In
tetrahydrofuran; dichloromethane;
2.1: Sharpless epoxidation / 3.1: Sharpless dihydroxylation;
DOI:10.1021/jo202199g
