Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Base Information

Chemical Name:Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me
CAS No.:1364705-47-4
Molecular Formula:C₃₄H₃₈ClN₃O₇
Molecular Weight:636.145
Hs Code.:

Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO<sub>2</sub>Me

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Chemical Property of Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

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Technology Process of Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

There total 10 articles about Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₅₀BClIN₃O₉

: 1364705-47-4
Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; In 1,4-dioxane; water; at 90 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo202105v

Reference yield:

: 71400-64-1
(S)-methyl 2-amino-3-(4-(benzyloxy)-3-iodophenyl)propanoate hydrochloride

: 1364705-47-4
Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; dichloromethane; water; 4: Suzuki-Miyaura cyclization;
DOI:10.1021/jo202105v

Reference yield:

: 851967-77-6
methyl (2S)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

: 1364705-47-4
Boc-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / hexane / 16 h / Inert atmosphere; Reflux

2.1: lithium hydrochloride monohydrate / methanol; water / 0.67 h / 20 °C / Inert atmosphere

2.2: pH 2 / Inert atmosphere

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; lithium hydrochloride monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,4-dioxane; methanol; hexane; dichloromethane; water; 4.1: Suzuki-Miyaura cyclization;
DOI:10.1021/jo202105v