C₁₉H₁₈ClN₃OS

Base Information

Chemical Name:C₁₉H₁₈ClN₃OS
CAS No.:1448631-54-6
Molecular Formula:C₁₉H₁₈ClN₃OS
Molecular Weight:371.89
Hs Code.:

C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>OS

Synonyms:

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Chemical Property of C₁₉H₁₈ClN₃OS

Chemical Property:

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Technology Process of C₁₉H₁₈ClN₃OS

There total 10 articles about C₁₉H₁₈ClN₃OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448631-52-4
C₂₀H₁₆ClN₃O₂S

: 1448631-54-6
C₁₉H₁₈ClN₃OS

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 90 ℃; for 1h;
DOI:10.1021/ml4001485

Reference yield:

: 1448631-44-4
C₂₄H₂₅ClN₂O₃S

: 1448631-54-6
C₁₉H₁₈ClN₃OS

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / chloroform / 36 °C

2: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 80 - 90 °C

3: sodium hydroxide / 1,4-dioxane; water / 1 h / 90 °C

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; chloroform; water; toluene;
DOI:10.1021/ml4001485

Reference yield:

: 1019115-42-4
methyl 2-bromo-4,5-dimethylthiophene-3-carboxylate

: 1448631-54-6
C₁₉H₁₈ClN₃OS

Guidance literature:: Multi-step reaction with 12 steps

1.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; butan-1-ol / 1 h / 100 °C / Inert atmosphere

2.1: sodium methylate; methanol / 1.5 h

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: titanium(IV) tetraethanolate / dichloromethane / 24 h / 20 °C

5.1: 1-methyl-pyrrolidin-2-one; diethyl ether / 6.17 h / -8.5 - 5 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 0.25 h / 20 °C

7.1: isopropylmagnesium bromide / tetrahydrofuran; 2-methyltetrahydrofuran / -20 - 20 °C

8.1: phosphorus pentachloride / dichloromethane / 1.5 h / 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; water / 95 °C

10.1: trifluoroacetic acid / chloroform / 36 °C

11.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 80 - 90 °C

12.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 90 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; titanium(IV) tetraethanolate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; phosphorus pentachloride; diphenyl phosphoryl azide; isopropylmagnesium bromide; sodium methylate; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; chloroform; water; toluene; butan-1-ol; 1.1: |Suzuki Coupling / 3.1: |Swern Oxidation / 3.2: |Swern Oxidation / 9.1: |Suzuki Coupling;
DOI:10.1021/ml4001485