Technology Process of 2-[2-[2-[5-Amino-2-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]acetamido]-3-phenylpropionyl]benzoxazole-5-carboxylic acid methyl ester
There total 9 articles about 2-[2-[2-[5-Amino-2-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]acetamido]-3-phenylpropionyl]benzoxazole-5-carboxylic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluorormethanesulfonic acid; methoxybenzene;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
DOI:10.1021/jm000496v
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / Et3N / CH2Cl2 / 4 h / 20 °C
2: HCl / CHCl3 / 3 h / 0 °C
3: ethanol / 6 h / Heating
4: H2 / 10percent Pd/C / methanol / 18 h / 20 °C
5: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C
6: 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3.5 h / 20 °C
7: trifluoromethanesulfonic acid; anisole / CH2Cl2 / 1 h / 0 - 20 °C
With
hydrogenchloride; dichloro-acetic acid; trifluorormethanesulfonic acid; hydrogen; dimethyl sulfoxide; methoxybenzene; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
10percent Pd/C;
In
methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
6: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000496v
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ethanol / 6 h / Heating
2: H2 / 10percent Pd/C / methanol / 18 h / 20 °C
3: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C
4: 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3.5 h / 20 °C
5: trifluoromethanesulfonic acid; anisole / CH2Cl2 / 1 h / 0 - 20 °C
With
dichloro-acetic acid; trifluorormethanesulfonic acid; hydrogen; dimethyl sulfoxide; methoxybenzene; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
10percent Pd/C;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
4: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000496v
![2-(2-{2-[5-benzyloxycarbonylamino-2-(3-methoxy-phenyl)-6-oxo-6<i>H</i>-pyrimidin-1-yl]-acetylamino}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
