4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide

Base Information

• Chemical Name: 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide
• CAS No.: 126645-71-4
• Molecular Formula: C₂₃H₃₀ClN₃O₃
• Molecular Weight: 431.963
• Mol file: 126645-71-4.mol

Synonyms:

Chemical Property of 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide

There total 7 articles about 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-2-chloromethylmorpholine (40987-25-5,186293-54-9) → 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide (126645-71-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) 140 deg C, 15 h

2: 98 percent / NaCl, H₂O / dimethylformamide / 23 h / Heating

3: 87 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 5 h / Ambient temperature

4: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 20 h / Ambient temperature

5: 54 percent / hydrazine monohydrate / ethanol / 1.5 h / Heating

6: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With water; sodium hydride; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium chloride; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00167a020

Reference yield:

4-benzyl-2-(3-hydroxypropyl)morpholine (126645-73-6) → 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide (126645-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 20 h / Ambient temperature

2: 54 percent / hydrazine monohydrate / ethanol / 1.5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00167a020

Reference yield:

N-<3-(4-benzyl-2-morpholinyl)propyl>phthalimide (126645-81-6) → 4-Amino-N-[3-(4-benzyl-morpholin-2-yl)-propyl]-5-chloro-2-ethoxy-benzamide (126645-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / hydrazine monohydrate / ethanol / 1.5 h / Heating

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

DOI:10.1021/jm00167a020

upstream raw materials:

4-amino-5-chloro-2-ethoxybenzoic acid

2-(3-aminopropyl)-4-benzylmorpholine

N-benzyl-2-chloromethylmorpholine

4-benzyl-2-(3-hydroxypropyl)morpholine