4-Benzyl-2-nitroaniline

Base Information

• Chemical Name: 4-Benzyl-2-nitroaniline
• CAS No.: 105957-88-8
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• Mol file: 105957-88-8.mol

Synonyms:4-Benzyl-2-nitro-phenylamine;4-Benzyl-2-nitro-anilin;

Chemical Property of 4-Benzyl-2-nitroaniline

Chemical Property:

• Melting Point: 78 °C (methanol)
• PSA: 71.84000
• LogP: 3.87220

Purity/Quality:

4-Benzyl-2-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Benzyl-2-nitroaniline is used as a reactant in the preparation of azetidinecarboxylic acid-containing (aryl)(benzyl)benzothiazoles as potent sphingosine-1-phosphate receptor agonists.

Technology Process of 4-Benzyl-2-nitroaniline

There total 3 articles about 4-Benzyl-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid-(4-benzyl-2-nitro-anilide) (500350-36-7) → 4-benzyl-2-nitro-aniline (105957-88-8)

Guidance literature:

With sulfuric acid;

Reference yield:

N-[4-(phenylmethyl)phenyl]acetamide (76472-81-6) → 4-benzyl-2-nitro-aniline (105957-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride; copper (II)-nitrate trihydrate

2: aq.-ethanolic sulfuric acid

With sulfuric acid; acetic anhydride; copper(II) nitrate;

Reference yield:

→ 6-benzyl-2-nitro-aniline (105957-89-9) + 4-benzyl-2-nitro-aniline (105957-88-8)

Guidance literature:

upstream raw materials:

acetic acid-(4-benzyl-2-nitro-anilide)

N-[4-(phenylmethyl)phenyl]acetamide

Refernces