76472-81-6

Basic information

• Product Name: Acetamide, N-[4-(phenylmethyl)phenyl]-
• CAS NO: 76472-81-6
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 76472-81-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-(phenylmethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-(phenylmethyl)phenyl]-(76472-81-6)
• EPA Substance Registry System: Acetamide, N-[4-(phenylmethyl)phenyl]-(76472-81-6)

Safety Data

• Hazardous Substances Data: 76472-81-6(Hazardous Substances Data)

Upstream product

• 1135-12-2 p-benzylaniline 
• 103-84-4 Acetanilid 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 5281-18-5 benzaldehyde, hydrazone 
• 301337-51-9 toluene-4-sulfonic acid 4-acetylaminophenyl ester 
• 100-52-7 benzaldehyde 
• 103-88-8 4-bromoacetanilide 
• 71-43-2 benzene 
• 623-10-9 N-(4-methylphenyl)hydroxylamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 3002-33-3 4-(3'-nitrobenzyl)-nitrobenzene 
• 71572-36-6 3-benzyl-1,5-dibromobenzene 
• 858846-68-1 4-benzyl-2-bromo-aniline 
• 858026-24-1 2,6-dibromo-4-phenylmethylaniline 
• 105957-88-8 4-benzyl-2-nitro-aniline 
• 872275-05-3 2-nitro-4-(4-nitro-benzyl)-aniline 
• 876496-87-6 acetic acid-[2-nitro-4-(4-nitro-benzyl)-anilide] 
• 500350-36-7 acetic acid-(4-benzyl-2-nitro-anilide) 

Relevant articles and documents

Nickel-Catalyzed Electrochemical C(sp3)?C(sp2) Cross-Coupling Reactions of Benzyl Trifluoroborate and Organic Halides**

Reported here is the redox neutral electrochemical C(sp2)?C(sp3) cross-coupling reaction of bench-stable aryl halides or β-bromostyrene (electrophiles) and benzylic trifluoroborates (nucleophiles) using nonprecious, bench-stable NiCl2?glyme/polypyridine catalysts in an undivided cell configuration under ambient conditions. The broad reaction scope and good yields of the Ni-catalyzed electrochemical coupling reactions were confirmed by 50 examples of aryl/β-styrenyl chloride/bromide and benzylic trifluoroborates. Potential applications were demonstrated by electrosynthesis and late-stage functionalization of pharmaceuticals and natural amino acid modification, and three reactions were run on gram-scale in a flow-cell electrolyzer. The electrochemical C?C cross-coupling reactions proceed through an unconventional radical transmetalation mechanism. This method is highly productive and expected to find wide-spread applications in organic synthesis.

Cross-Coupling of Phenol Derivatives with Umpolung Aldehydes Catalyzed by Nickel

A nickel-catalyzed cross-coupling to construct the C(sp2)-C(sp3) bond was developed from two sustainable biomass-based feedstocks: phenol derivatives with umpolung aldehydes. This strategy features the in situ generation of moisture/air-stable hydrazones from naturally abundant aldehydes, which act as alkyl nucleophiles under catalysis to couple with readily available phenol derivatives. The avoidance of using both halides as the electrophiles and organometallic or organoboron reagents (also derived from halides) as the nucleophiles makes this method more sustainable. Water tolerance, great functional group (ketone, ester, free amine, amide, etc.) compatibility, and late-stage elaboration of complex biological molecules exemplified its practicability and unique chemoselectivity over organometallic reagents.

Solvent free acid catalysed direct N-alkylation of amines with alcohols using Al grafted MCM-41

The catalytic activity of Al grafted MCM-41 (Al-MS) was explored for solvent free acid catalysed direct N-alkylation of amines using alcohols as green alkylating agent to establish a clean method for synthesis of N-alkylated amines. The study revealed that acidity of Al-MS catalyst, reaction conditions and substrate's (amines and alcohols) nature are important factors influencing the N-alkylation reaction. The Al grafted MCM-41 with Si/Al molar ratio of 5 showed excellent activity for N-alkylation of amines with alcohols. The reusability of spent catalyst regenerated by simple washing with acetone was demonstrated for subsequent four reaction cycles.