2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester
• CAS No.: 228873-35-6
• Molecular Formula: C₃₃H₅₄O₁₂
• Molecular Weight: 642.785
• Mol file: 228873-35-6.mol

Synonyms:

Chemical Property of 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester

There total 2 articles about 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexyl succinimidylcarbonate (128595-08-4) + 2,3,4,6-Tetra-O-pivaloyl-α/β-D-glucopyranose (148968-87-0) → 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester (228873-35-6) + 2,2-Dimethyl-propionic acid (2R,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester

Guidance literature:

With potassium carbonate; In toluene; at 20 ℃; for 20h;

DOI:10.1016/S0040-4039(99)00843-6

Reference yield:

cyclohexanol (108-93-0) → 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester (228873-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / acetonitrile / 20 °C

2: K₂CO₃ / toluene / 20 h / 20 °C

With potassium carbonate; triethylamine; In toluene; acetonitrile; 1: Esterification / 2: Esterification;

DOI:10.1016/S0040-4039(99)00843-6

Reference yield:

2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxycarbonyloxy-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester (228873-35-6) → 2,2-Dimethyl-propionic acid (2R,3R,4S,5R,6R)-2-cyclohexyloxy-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester + 2,2-Dimethyl-propionic acid (2S,3R,4S,5R,6R)-2-cyclohexyloxy-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -30 - 0 ℃; for 1.2h;

DOI:10.1016/S0040-4039(99)00843-6

upstream raw materials:

cyclohexyl succinimidylcarbonate

2,3,4,6-Tetra-O-pivaloyl-α/β-D-glucopyranose

cyclohexanol