[4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester

Base Information

Chemical Name:[4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester
CAS No.:483987-37-7
Molecular Formula:C₂₉H₂₆O₅
Molecular Weight:454.522
Hs Code.:

[4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid <i>tert</i>-butyl ester

Synonyms:

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Chemical Property of [4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester

Chemical Property:

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Technology Process of [4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester

There total 12 articles about [4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 483987-37-7
[4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃; KI / acetone / Heating

2: H₂ / 10 percent Pd/C / ethanol / 20 °C

3: (PhSeO)2O / tetrahydrofuran / 50 °C

4: Pd(OAc)2; AcOH / Heating

With palladium diacetate; (PhSeO)2O; hydrogen; potassium carbonate; acetic acid; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/S0960-894X(02)00331-1

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 483987-37-7
[4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran / 0 °C

1.2: tetrahydrofuran / -20 - 0 °C

2.1: Et₃SiH; TFA / CH₂Cl₂ / 0 °C

3.1: TBAF / tetrahydrofuran / 0 °C

4.1: K₂CO₃; KI / acetone / Heating

5.1: H₂ / 10 percent Pd/C / ethanol / 20 °C

6.1: (PhSeO)2O / tetrahydrofuran / 50 °C

7.1: Pd(OAc)2; AcOH / Heating

With triethylsilane; palladium diacetate; n-butyllithium; (PhSeO)2O; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1016/S0960-894X(02)00331-1

Reference yield:

: 128019-31-8
3-benzyloxy-[2]naphthoic acid

: 483987-37-7
[4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: LiAlH₄ / tetrahydrofuran / 0 °C

2.1: MnO₂ / dioxane / 20 °C

3.1: n-BuLi / tetrahydrofuran / 0 °C

3.2: tetrahydrofuran / -20 - 0 °C

4.1: Et₃SiH; TFA / CH₂Cl₂ / 0 °C

5.1: TBAF / tetrahydrofuran / 0 °C

6.1: K₂CO₃; KI / acetone / Heating

7.1: H₂ / 10 percent Pd/C / ethanol / 20 °C

8.1: (PhSeO)2O / tetrahydrofuran / 50 °C

9.1: Pd(OAc)2; AcOH / Heating

With triethylsilane; manganese(IV) oxide; palladium diacetate; lithium aluminium tetrahydride; n-butyllithium; (PhSeO)2O; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone;
DOI:10.1016/S0960-894X(02)00331-1