128019-31-8

Upstream product

• 100-44-7 benzyl chloride 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 100-39-0 benzyl bromide 
• 203807-48-1 3-benzyloxy-naphthalene-2-carboxylic acid, benzyl ester 

Downstream Products

• 217176-33-5 (3-(benzyloxy)naphthalen-2-yl)methanol 
• 220328-44-9 3-benzyloxynaphthalene-2-carbaldehyde 
• 483987-37-7 [4-(3,4-dioxo-1-phenyl-3,4-dihydro-naphthalen-2-ylmethyl)-phenoxy]-acetic acid tert-butyl ester 
• 483987-38-8 {4-[1-(1H-indol-3-yl)-3,4-dioxo-3,4-dihydro-naphthalen-2-ylmethyl]-phenoxy}-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Preparation of enantioenriched helical- and axial-chiral molecules by dynamic asymmetric induction

Dynamic asymmetric induction (DYASIN) of racemic dynamic chiral heterohelicenes afforded their highly enantioenriched forms (up to 96% ep) in quantitative yields. These heterohelicenes were readily converted into semi-static axial-chiral 1,1′-binaphthyl derivatives in a stereospecific manner.

Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F–H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π–π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.

A new series of 1,2-naphthoquinone derivatives was synthesized by various synthetic methods and evaluated for their ability to inhibit protein tyrosine phosphatase 1B (PTP1B). 1,2-Naphthoquinone derivatives with substituent at R(4) position showed submicromolar inhibitory activity, and compound 24 demonstrated 10- to 60-fold selectivity against the tested phosphatases. Also, several 4-aryl-1,2-naphthoquinone derivatives with substituents at R(3), R(6), R(7), or/and R(8) showed submicromolar inhibitory activity and good plasma stability.

Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore

The preparation and examination of 2-22 constituting a systematic study of the chromophore of sandramycin (1) are detailed. Fluorescence quenching studies were used to establish binding constants for 1-24 within calf thymus DNA, within a single high affin