4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

Base Information

Chemical Name:4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester
CAS No.:108932-21-4
Molecular Formula:C₃₆H₃₈F₃N₃O₅S
Molecular Weight:681.776
Hs Code.:

4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

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Chemical Property of 4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

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Technology Process of 4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

There total 6 articles about 4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-44-5
phosgene

: 4727-72-4
1-benzyl-4-hydroxypiperidine

: 142930-09-4
1,4-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-6-methyl-4-[2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid, ethyl ester

: 108932-21-4
4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

Guidance literature:: In pyridine; toluene;

Reference yield:

: 114957-75-4
2-[[2-(trifluoromethyl)phenyl]methylene]-3-oxobutanoic acid,ethyl ester

: 108932-21-4
4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

2: pyridine / acetonitrile; toluene / 6 h / Ambient temperature

3: 6.4 g / acetonitrile / 16 h / Ambient temperature

With pyridine; sodium acetate; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo00286a020

Reference yield:

: 25985-08-4
2-(4-methoxybenzyl)isothiourea hydrochloride

: 108932-21-4
4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

2: pyridine / acetonitrile; toluene / 6 h / Ambient temperature

3: 6.4 g / acetonitrile / 16 h / Ambient temperature

With pyridine; sodium acetate; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo00286a020