1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol

Base Information

• Chemical Name: 1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol
• CAS No.: 92399-37-6
• Molecular Formula: C₁₈H₁₉NO₄S
• Molecular Weight: 345.419
• Mol file: 92399-37-6.mol

Synonyms:

Chemical Property of 1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol

There total 2 articles about 1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → 1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol (92399-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide / 1.) 1.5h, -70 deg C to room temp., 2.) -70 deg C to room temp.

With lithium diisopropyl amide;

DOI:10.1021/jo00197a039

Reference yield:

1-(phenylsulfonyl)indole-3-carbaldehyde (80360-20-9) + methyllithium (917-54-4) + acetaldehyde (75-07-0,9002-91-9) → 1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol (92399-37-6)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)94105-4 DOI:10.1021/jo00197a039

Reference yield:

1-[1-Benzenesulfonyl-3-(1-hydroxy-ethyl)-1H-indol-2-yl]-ethanol (92399-37-6) → 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole (89241-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: brown MnO₂ / CHCl₃ / 26 h / Heating

2: anhydrous Na₂SO₄, trifluoroacetic acid / CH₂Cl₂ / 0.92 h / Heating

With manganese(IV) oxide; sodium sulfate; trifluoroacetic acid; In dichloromethane; chloroform;

DOI:10.1021/jo00197a039

upstream raw materials:

1-(phenylsulfonyl)indole-3-carbaldehyde

methyllithium

acetaldehyde

Indole-3-carboxaldehyde

Downstream raw materials:

4-Benzenesulfonyl-1,3-dimethyl-3,4-dihydro-1H-furo[3,4-b]indol-1-ol

1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole

5-(Phenylsulfonyl)-6,11-epoxy-6,11-dimethyl-6,11-dihydrobenzocarbazole

10-(Phenylsulfonyl)-5,11-epoxy-5,11-dimethyl-5,11-dihydropyrido<3.4-b>carbazole