Technology Process of Acetic acid (1S,4R)-5-acetoxy-4-benzyloxy-1-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-ylmethyl)-pentyl ester
There total 17 articles about Acetic acid (1S,4R)-5-acetoxy-4-benzyloxy-1-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-ylmethyl)-pentyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium p-toluenesulfonate;
In
dichloromethane; acetone;
for 2h;
Ambient temperature;
DOI:10.1016/S0040-4020(01)86915-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 43 percent / diethyl (+)-tartrate, Ti(Oi-Pr)4, TBHP / CH2Cl2 / 48 h / -20 °C / diethyl (-)-tartrate instead of diethyl (+)-tartrate
2: PPTS / CH2Cl2 / 5 h
3: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Ambient temperature
4: 96 percent / pyridine / Ambient temperature
5: 96 percent / MeOH, PPTS / 1.5 h / 50 °C
6: 82 percent / PPTS / acetone; CH2Cl2 / 2 h / Ambient temperature
With
pyridine; titanium(IV) isopropylate; methanol; tert.-butylhydroperoxide; lithium aluminium tetrahydride; diethyl (2R,3R)-tartrate; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)86915-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 43 percent / diethyl (-)-tartrate, Ti(Oi-Pr)4, TBHP / CH2Cl2 / 48 h / -20 °C / diethyl (+)-tartrate instead of diethyl (-)-tartrate
2: PPTS / CH2Cl2 / 5 h
3: lithium aluminum hydride / tetrahydrofuran / 2 h / Ambient temperature
4: pyridine / Ambient temperature
5: MeOH, PPTS / 1.5 h / 50 °C
6: PPTS / acetone; CH2Cl2 / 2 h / Ambient temperature
With
pyridine; titanium(IV) isopropylate; methanol; tert.-butylhydroperoxide; lithium aluminium tetrahydride; diethyl (2S,3S)-tartrate; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)86915-5
