4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

Base Information

Chemical Name:4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester
CAS No.:241824-01-1
Molecular Formula:C₅₀H₄₇F₇N₂O₈
Molecular Weight:936.921
Hs Code.:

4-(2-<i>tert</i>-butoxy-1-<i>tert</i>-butoxycarbonyl-ethylcarbamoyl)-4-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

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Chemical Property of 4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

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Technology Process of 4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

There total 6 articles about 4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 48067-24-9
O-tert-butyl L-serine tert-butyl ester

: 241823-99-4
2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester

: 241824-01-1
4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate;

Reference yield:

: 344-04-7
bromopentafluorobenzene

: 241824-01-1
4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg / diethyl ether

1.2: 94 percent / diethyl ether / 3 h / Heating

2.1: 100 percent / SOCl₂ / 0.17 h / 20 °C

3.1: 84 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

4.1: 82 percent / PhNHMe / Pd(PPh₃)4

5.1: 91 percent / DIPEA; tetramethylfluoroformamidinium hexafluorophosphate

With thionyl chloride; magnesium; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution / 3.1: Alkylation / 4.1: Deallylation / 5.1: Acylation;

Reference yield:

: 345-92-6
4,4'-Difluorobenzophenone

: 241824-01-1
4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg / diethyl ether

1.2: 94 percent / diethyl ether / 3 h / Heating

2.1: 100 percent / SOCl₂ / 0.17 h / 20 °C

3.1: 84 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

4.1: 82 percent / PhNHMe / Pd(PPh₃)4

5.1: 91 percent / DIPEA; tetramethylfluoroformamidinium hexafluorophosphate

With thionyl chloride; magnesium; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution / 3.1: Alkylation / 4.1: Deallylation / 5.1: Acylation;