Technology Process of (3S,5S)-3,5-bis(benzoyloxy)heptane-1,7-dinitrile
There total 5 articles about (3S,5S)-3,5-bis(benzoyloxy)heptane-1,7-dinitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / pyridine / Ambient temperature
2: 1.) DBU, 2.) H2 / 2.) 10percent palladium on carbon / 1.) THF, -78 deg C, 4 h, 2.) ethanol
3: 86 percent / sodium borohydride, boric acid, Amberlyte IR 120H+ resin / H2O / 1.) 0 deg C, 1.5 h, 2.) room temperature, overnight
4: 88 percent / pyridine / 5 °C
5: 2.) pyridine / 1.) methanol, reflux, 3 h, 2.) room temperature, overnight
With
pyridine; sodium tetrahydroborate; Amberlyte IR 120H+ resin; hydrogen; boric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) DBU, 2.) H2 / 2.) 10percent palladium on carbon / 1.) THF, -78 deg C, 4 h, 2.) ethanol
2: 86 percent / sodium borohydride, boric acid, Amberlyte IR 120H+ resin / H2O / 1.) 0 deg C, 1.5 h, 2.) room temperature, overnight
3: 88 percent / pyridine / 5 °C
4: 2.) pyridine / 1.) methanol, reflux, 3 h, 2.) room temperature, overnight
With
pyridine; sodium tetrahydroborate; Amberlyte IR 120H+ resin; hydrogen; boric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 86 percent / sodium borohydride, boric acid, Amberlyte IR 120H+ resin / H2O / 1.) 0 deg C, 1.5 h, 2.) room temperature, overnight
2: 88 percent / pyridine / 5 °C
3: 2.) pyridine / 1.) methanol, reflux, 3 h, 2.) room temperature, overnight
With
pyridine; sodium tetrahydroborate; Amberlyte IR 120H+ resin; boric acid;
In
water;
