AG 013736-d3

Base Information

Chemical Name:AG 013736-d3
CAS No.:1126623-89-9
Molecular Formula:C₂₂H₁₈N₄OS
Molecular Weight:389.453
Hs Code.:
Mol file:1126623-89-9.mol

Synonyms:

Suppliers and Price of AG 013736-d3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Axitinib-d3
250ug
$ 638.00

TRC
Axitinib-d3
10mg
$ 11800.00

Total 6 raw suppliers

Chemical Property of AG 013736-d3

Chemical Property:

Purity/Quality:

95% by HPLC; 98% atom D ^*data from raw suppliers

Axitinib-d3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses AG 013736-d3 is a labelled analogue of Axitinib, a tyrosine kinase inhibitor. It is used in cancer therapy.

Technology Process of AG 013736-d3

There total 4 articles about AG 013736-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

: 6-((2-((t-butoxycarbonyl)(methyl)carbamoyl)phenyl)thio)-3-(2-(pyridin-2-yl)ethylenyl)-1H-indazol-1-carboxylic acid (E)-t-butyl ester

: 7436-22-8
methyl-d3-amine hydrochloride

: 1126623-89-9
C₂₂H₁₅⁽²⁾H₃N₄OS

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25 ℃; for 12h;

Reference yield: 36.9%

: C₂₇H₂₃⁽²⁾H₃N₄O₂S

: 1126623-89-9
C₂₂H₁₅⁽²⁾H₃N₄OS

Guidance literature:: With hydrogenchloride; In methanol; water; at 60 ℃; for 4h;

Reference yield:

: C₈H₆⁽²⁾H₃NOS

: 1126623-89-9
C₂₂H₁₅⁽²⁾H₃N₄OS

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogenchloride / water; methanol / 4 h / 60 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In methanol; water; N,N-dimethyl-formamide;