2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)butoxy]-

Base Information

• Chemical Name: 2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)butoxy]-
• CAS No.: 105966-45-8
• Molecular Formula: C16H24O3
• Molecular Weight: 264.365
• DSSTox Substance ID: DTXSID80471077
• Nikkaji Number: J1.160.767E
• Mol file: 105966-45-8.mol

Synonyms:105966-45-8;2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)butoxy]-;DTXSID80471077

Chemical Property of 2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)butoxy]-

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 264.17254462
• Heavy Atom Count: 19
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCOC(C1)OCCCCOCC2=CC=CC=C2

Technology Process of 2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)butoxy]-

There total 3 articles about 2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)butoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-benzyloxy-butan-1-ol (4541-14-4) → 2-[4-(benzyloxy)butoxy]tetrahydro-2H-pyran (105966-45-8)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1246/bcsj.75.367

Reference yield: 93.0%

2-acetoxytetrahydropyran (2761-33-3) + [4-(benzyloxy)butoxy](tert-butyl)dimethylsilane (105966-46-9) → 2-[4-(benzyloxy)butoxy]tetrahydro-2H-pyran (105966-45-8)

Guidance literature:

2-acetoxytetrahydropyran; [4-(benzyloxy)butoxy](tert-butyl)dimethylsilane; With t-butyldimethylsiyl triflate; In various solvent(s); at -78 ℃;

With triethylamine; In various solvent(s); at -78 ℃; for 0.0833333h;

DOI:10.1055/s-2001-12343

Reference yield: 83.0%

benzaldehyde (100-52-7) + trimethyl-[4-(tetrahydro-pyran-2-yloxy)-butoxy]-silane (733768-75-7) → 2-[4-(benzyloxy)butoxy]tetrahydro-2H-pyran (105966-45-8)

Guidance literature:

With polymethylhydrosiloxane; tris(pentafluorophenyl)borate; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2004.05.061

upstream raw materials:

2-acetoxytetrahydropyran

[4-(benzyloxy)butoxy](tert-butyl)dimethylsilane

3,4-dihydro-2H-pyran

4-benzyloxy-butan-1-ol

Downstream raw materials:

4-benzyloxybutyl acetate

4-benzyloxy-butan-1-ol

1,4-bis(dibenzyloxy)butane