(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Base Information

Chemical Name:(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide
CAS No.:443123-84-0
Molecular Formula:C₃₇H₆₅NO₅Si₂
Molecular Weight:660.098
Hs Code.:

(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Synonyms:

Suppliers and Price of (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

There total 11 articles about (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2,6-bis-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-hexyl]-amide

: 443123-84-0
(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; at 0 ℃; for 5h;
DOI:10.1016/S0040-4039(02)00289-7

Reference yield:

: 83067-20-3
5-(tert-butyldimethyl-silyloxy)pentan-1-ol

: 443123-84-0
(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Guidance literature:: Multi-step reaction with 11 steps

1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / -78 °C

2: PPh₃; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: nBuLi / tetrahydrofuran / 0.5 h / -78 °C

4: camphorsulfonic acid / methanol; CH₂Cl₂ / 0.5 h / 0 °C

5: H₂ / Lindlar's catalyst / hexane

6: 79 percent / mCPBA / CH₂Cl₂ / 0.75 h / 0 - 20 °C

7: 88 percent / NaN₃; NH₄Cl / methanol; H₂O / 15 h / 0 - 20 °C

8: LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

9: EDCI; HOBt / CH₂Cl₂ / 5.25 h / 0 - 20 °C

10: 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

11: camphorsulfonic acid / methanol; CH₂Cl₂ / 5 h / 0 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; n-butyllithium; sodium azide; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; ammonium chloride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; 1: Swern oxidation;
DOI:10.1016/S0040-4039(02)00289-7

Reference yield:

: 87184-80-3
5-tert-butyldimethylsilyloxypentanal

: 443123-84-0
(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid [2-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-trimethylsilanyl-hexyl]-amide

Guidance literature:: Multi-step reaction with 10 steps

1: PPh₃; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: nBuLi / tetrahydrofuran / 0.5 h / -78 °C

3: camphorsulfonic acid / methanol; CH₂Cl₂ / 0.5 h / 0 °C

4: H₂ / Lindlar's catalyst / hexane

5: 79 percent / mCPBA / CH₂Cl₂ / 0.75 h / 0 - 20 °C

6: 88 percent / NaN₃; NH₄Cl / methanol; H₂O / 15 h / 0 - 20 °C

7: LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

8: EDCI; HOBt / CH₂Cl₂ / 5.25 h / 0 - 20 °C

9: 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

10: camphorsulfonic acid / methanol; CH₂Cl₂ / 5 h / 0 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; n-butyllithium; sodium azide; camphor-10-sulfonic acid; hydrogen; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
DOI:10.1016/S0040-4039(02)00289-7