ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

Base Information

• Chemical Name: ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate
• CAS No.: 538370-08-0
• Molecular Formula: C₂₀H₁₉N₃O₄S₂
• Molecular Weight: 429.521
• Mol file: 538370-08-0.mol

Synonyms:

Chemical Property of ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

There total 3 articles about ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.9%

α-bromoacetophenone (70-11-1) + diethyl 4-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylate (258330-07-3) → ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate (538370-08-0)

Guidance literature:

With potassium carbonate; In acetone; for 20h;

DOI:10.1080/10426500307772

Reference yield:

diethyl 2({[(benzoyl)amino]carbothioyl}amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylate (538370-01-3) → ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate (538370-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / methanol / 6 h / Heating

2: 0.48 g / aq. HCl / methanol / 0.5 h / 20 °C / pH 5.6

3: 67.9 percent / K₂CO₃ / acetone / 20 h

With hydrogenchloride; sodium hydroxide; potassium carbonate; In methanol; acetone;

DOI:10.1080/10426500307772

Reference yield:

3-Benzoyl-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydro-2H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid ethyl ester → ethyl 2-[(2-phenyl-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate (538370-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.48 g / aq. HCl / methanol / 0.5 h / 20 °C / pH 5.6

2: 67.9 percent / K₂CO₃ / acetone / 20 h

With hydrogenchloride; potassium carbonate; In methanol; acetone;

DOI:10.1080/10426500307772

upstream raw materials:

α-bromoacetophenone

diethyl 4-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylate

diethyl 2({[(benzoyl)amino]carbothioyl}amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylate