5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

Base Information

Chemical Name:5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide
CAS No.:1053635-97-4
Molecular Formula:C₄₆H₅₆FN₅O₆Si
Molecular Weight:822.064
Hs Code.:

5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

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Chemical Property of 5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

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Technology Process of 5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

There total 4 articles about 5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 709-45-5
2-fluoro-5-bromomethyl benzoic acid methyl ester

: 1053635-97-4
5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: KI / acetonitrile / 6 h / Heating

2: 1N NaOH / dioxane / 24 h / Ambient temperature

3: CBr₄, Ph₃P, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; sodium hydroxide; carbon tetrabromide; triphenylphosphine; potassium iodide; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm980103g

Reference yield:

: (3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-5-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

: 1053635-97-4
5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: KI / acetonitrile / 6 h / Heating

2: 1N NaOH / dioxane / 24 h / Ambient temperature

3: CBr₄, Ph₃P, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; sodium hydroxide; carbon tetrabromide; triphenylphosphine; potassium iodide; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm980103g

Reference yield:

: 1053721-45-1
5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-benzoic acid methyl ester

: 1053635-97-4
5-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-2-fluoro-N-methoxy-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1N NaOH / dioxane / 24 h / Ambient temperature

2: CBr₄, Ph₃P, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; sodium hydroxide; carbon tetrabromide; triphenylphosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm980103g