8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile

Base Information

Chemical Name:8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile
CAS No.:900512-99-4
Molecular Formula:C₁₈H₁₂N₄O₂S
Molecular Weight:348.385
Hs Code.:

8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-<i>f</i>]quinazoline-2-carbonitrile

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Chemical Property of 8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile

Chemical Property:

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Technology Process of 8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile

There total 6 articles about 8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 900513-13-5
3-(4-methoxybenzyl)-6-nitroquinazolin-4-(3H)-one

: 900512-99-4
8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: HCO₂NH₄ / Pd/C / ethanol / 0.5 h / 80 °C / microvawe irradiation

2: Br₂; AcOH / 2 h / 20 °C

3: pyridine / CH₂Cl₂ / 1 h / 20 °C

4: pyridine; CuI / 0.25 h / 115 °C / microwave irradiation

With pyridine; copper(l) iodide; bromine; ammonium formate; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.006

Reference yield:

: 6943-17-5
6-nitroquinazolone

: 900512-99-4
8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide / 0.5 h / microvawe irradiation

2: HCO₂NH₄ / Pd/C / ethanol / 0.5 h / 80 °C / microvawe irradiation

3: Br₂; AcOH / 2 h / 20 °C

4: pyridine / CH₂Cl₂ / 1 h / 20 °C

5: pyridine; CuI / 0.25 h / 115 °C / microwave irradiation

With pyridine; copper(l) iodide; bromine; ammonium formate; sodium hydride; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.006

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 900512-99-4
8-(4-methoxy-benzyl)-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide / 0.5 h / microvawe irradiation

2: HCO₂NH₄ / Pd/C / ethanol / 0.5 h / 80 °C / microvawe irradiation

3: Br₂; AcOH / 2 h / 20 °C

4: pyridine / CH₂Cl₂ / 1 h / 20 °C

5: pyridine; CuI / 0.25 h / 115 °C / microwave irradiation

With pyridine; copper(l) iodide; bromine; ammonium formate; sodium hydride; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.006