(E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride

Base Information

• Chemical Name: (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride
• CAS No.: 85278-07-5
• Molecular Formula: C₁₀H₁₂FNO*ClH
• Molecular Weight: 217.671
• Mol file: 85278-07-5.mol

Synonyms:

Chemical Property of (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride

There total 7 articles about (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl α-(2-methopxyphenyl)acetate (63730-75-6) → (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride (85278-07-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) LDA / 1.) THF, -78 deg C, 1h, 2.) THF, overnight

2: 1.) sodium tert-butoxide / 1.) THF, 15 min, 2.) THF, 30 min

3: trifluoroacetic acid / 1 h / Ambient temperature

4: 2M aq. NaOH / tetrahydrofuran / 0.25 h / Ambient temperature

5: 1M Dibal / hexane; CH₂Cl₂ / 1 h / Ambient temperature

6: triphenylphonsphine, diethyl azodiacrboxylate / tetrahydrofuran

7: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min

With hydrogenchloride; sodium hydroxide; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid; sodium t-butanolate; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm00380a007

Reference yield:

(E)-2-(2'-methoxy)phenyl-3-fluoroallyl alcohol (85277-89-0) → (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride (85278-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphonsphine, diethyl azodiacrboxylate / tetrahydrofuran

2: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min

With hydrogenchloride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/jm00380a007

Reference yield:

Ethyl (E)-2-(2'-methoxy)phenyl-3-fluoroacrylate (85277-80-1) → (E)-3-Fluoro-2-(2-methoxy-phenyl)-allylamine; hydrochloride (85278-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1M Dibal / hexane; CH₂Cl₂ / 1 h / Ambient temperature

2: triphenylphonsphine, diethyl azodiacrboxylate / tetrahydrofuran

3: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min

With hydrogenchloride; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm00380a007

upstream raw materials:

(E)1-Fluoro-2-(2'-methoxy)phenyl-3-phthalimidopropene

tert-butyl α-(2-methopxyphenyl)acetate

(E)-2-(2'-methoxy)phenyl-3-fluoroallyl alcohol

Ethyl (E)-2-(2'-methoxy)phenyl-3-fluoroacrylate