C₄₉H₇₁N₅O₁₄*C₂HF₃O₂

Base Information Edit

Chemical Name:C₄₉H₇₁N₅O₁₄*C₂HF₃O₂
CAS No.:117710-29-9
Molecular Formula:C₂HF₃O₂*C₄₉H₇₁N₅O₁₄
Molecular Weight:1068.15
Hs Code.:
Mol file:117710-29-9.mol

C<sub>49</sub>H<sub>71</sub>N<sub>5</sub>O<sub>14</sub>*C<sub>2</sub>HF<sub>3</sub>O<sub>2</sub>

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Chemical Property of C₄₉H₇₁N₅O₁₄*C₂HF₃O₂ Edit

Chemical Property:

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Technology Process of C₄₉H₇₁N₅O₁₄*C₂HF₃O₂

There total 12 articles about C₄₉H₇₁N₅O₁₄*C₂HF₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 117710-29-9,117773-54-3
C₄₉H₇₁N₅O₁₄*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 12 steps

1: 98 percent / triethylamine (TEA) / tetrahydrofuran / 2 h / 0 - 5 °C

2: lithium diisopropylamide / 1.) THF, hexane, from -78 deg C to -70 deg C, 15 min

3: NaBH₄ / CH₂Cl₂; acetic acid / 1 h / 0 - 5 °C

4: p-toluenesulfonic acid / 1.) reflux, 3 h, 2.) room temperature, overnight

5: 98 percent / 2 M NaOH / methanol / 0 - 5 °C

6: 92 percent / triethylamine (TEA), 4-(dimethylamino)pyridine (DMAP), isopropenyl chlorocarbonate (IPCC) / CH₂Cl₂ / 0.25 h / -5 °C

7: 100 percent / H₂ / 10percent Pd/C / propan-2-ol / 760 Torr

8: 97 percent / triethylamine (TEA) / tetrahydrofuran / 2 h / 0 - 5 °C

9: lithium diisopropylamide / 1.) THF, hexane, from -78 deg C to -70 deg C, 15 min

10: triethylamine (TEA), CuI / CH₂Cl₂ / 0.5 h / Ambient temperature

11: morpholine / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 0.17 h

12: 0.5 h

With morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; Isopropenyl chloroformate; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; acetic acid; isopropyl alcohol;
DOI:10.1021/jo00264a022

Reference yield:

: 117710-06-2
(R)-4-tert-Butoxycarbonylamino-3-hydroxy-5-methyl-hexanoic acid ethyl ester

: 117710-29-9,117773-54-3
C₄₉H₇₁N₅O₁₄*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 9 steps

1: p-toluenesulfonic acid / 1.) reflux, 3 h, 2.) room temperature, overnight

2: 98 percent / 2 M NaOH / methanol / 0 - 5 °C

3: 92 percent / triethylamine (TEA), 4-(dimethylamino)pyridine (DMAP), isopropenyl chlorocarbonate (IPCC) / CH₂Cl₂ / 0.25 h / -5 °C

4: 100 percent / H₂ / 10percent Pd/C / propan-2-ol / 760 Torr

5: 97 percent / triethylamine (TEA) / tetrahydrofuran / 2 h / 0 - 5 °C

6: lithium diisopropylamide / 1.) THF, hexane, from -78 deg C to -70 deg C, 15 min

7: triethylamine (TEA), CuI / CH₂Cl₂ / 0.5 h / Ambient temperature

8: morpholine / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 0.17 h

9: 0.5 h

With morpholine; dmap; sodium hydroxide; copper(l) iodide; Isopropenyl chloroformate; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo00264a022

Reference yield:

: 117710-05-1
ethyl (4R)-4-<(tert-butyloxycarbonyl)amino>-3-oxo-5-methylhexanoate

: 117710-29-9,117773-54-3
C₄₉H₇₁N₅O₁₄*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 10 steps

1: NaBH₄ / CH₂Cl₂; acetic acid / 1 h / 0 - 5 °C

2: p-toluenesulfonic acid / 1.) reflux, 3 h, 2.) room temperature, overnight

3: 98 percent / 2 M NaOH / methanol / 0 - 5 °C

4: 92 percent / triethylamine (TEA), 4-(dimethylamino)pyridine (DMAP), isopropenyl chlorocarbonate (IPCC) / CH₂Cl₂ / 0.25 h / -5 °C

5: 100 percent / H₂ / 10percent Pd/C / propan-2-ol / 760 Torr

6: 97 percent / triethylamine (TEA) / tetrahydrofuran / 2 h / 0 - 5 °C

7: lithium diisopropylamide / 1.) THF, hexane, from -78 deg C to -70 deg C, 15 min

8: triethylamine (TEA), CuI / CH₂Cl₂ / 0.5 h / Ambient temperature

9: morpholine / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 0.17 h

10: 0.5 h

With morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; Isopropenyl chloroformate; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; acetic acid; isopropyl alcohol;
DOI:10.1021/jo00264a022