2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide

Base Information

Chemical Name:2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide
CAS No.:894763-37-2
Molecular Formula:C₂₃H₃₆N₆O₁₀
Molecular Weight:556.573
Hs Code.:

2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-<i>N</i>-(2-hydroxy-ethyl)-acetamide

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Chemical Property of 2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide

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Technology Process of 2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide

There total 6 articles about 2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 894763-34-9
{[5-benzyloxy-2-(bis-ethoxycarbonylmethyl-amino)-phenyl]-ethoxycarbonylmethyl-amino}-acetic acid ethyl ester

: 894763-37-2
2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / pyridine; phosphorus oxychloride / 9.5 h / 0 - 20 °C

2.1: 93 percent / cyclohexene / Pd/C / tetrahydrofuran / 3 h / Heating

3.1: acetonitrile / 2.5 h / Heating

3.2: 0.19 g / trifluoroacetic acid / methanol; H₂O / 0.17 h / 50 °C

With pyridine; cyclohexene; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo052642g

Reference yield:

: 894763-35-0
{[5-benzyloxy-2-(bis-ethoxycarbonylmethyl-amino)-4-formyl-phenyl]-ethoxycarbonylmethyl-amino}-acetic acid ethyl ester

: 894763-37-2
2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / cyclohexene / Pd/C / tetrahydrofuran / 3 h / Heating

2.1: acetonitrile / 2.5 h / Heating

2.2: 0.19 g / trifluoroacetic acid / methanol; H₂O / 0.17 h / 50 °C

With cyclohexene; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo052642g

Reference yield:

: 610-81-1
4-hydroxy-2-nitroaniline

: 894763-37-2
2-{(2-{bis-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-4-formyl-5-hydroxy-phenyl)-[(2-hydroxy-ethylcarbamoyl)-methyl]-amino}-N-(2-hydroxy-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 60 percent / KOH; tetrabutylammonium bromide / H₂O; CH₂Cl₂ / 8 h / 20 °C

2.1: 85 percent / SnCl₂*2H₂O / H₂O; acetonitrile; ethanol / 3 h / Heating

3.1: 61 percent / sodium iodide; N,N-diisopropylethylamine / acetonitrile / 7 h / Heating

4.1: 80 percent / pyridine; phosphorus oxychloride / 9.5 h / 0 - 20 °C

5.1: 93 percent / cyclohexene / Pd/C / tetrahydrofuran / 3 h / Heating

6.1: acetonitrile / 2.5 h / Heating

6.2: 0.19 g / trifluoroacetic acid / methanol; H₂O / 0.17 h / 50 °C

With pyridine; potassium hydroxide; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; sodium iodide; tin(ll) chloride; cyclohexene; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo052642g