Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

Base Information

Chemical Name:Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-
CAS No.:141283-52-5
Molecular Formula:C₁₄H₁₈F₃N₃O₃S
Molecular Weight:365.376
Hs Code.:
DSSTox Substance ID:DTXSID00161625
Wikidata:Q83030060

Synonyms:Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-;N-(2-((Methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)cyclohexanecarboxamide;141283-52-5;SCHEMBL6256099;C14H18F3N3O3S;DTXSID00161625;AXHKEINTIBWKLT-UHFFFAOYSA-N;C14-H18-F3-N3-O3-S;LS-56588

Suppliers and Price of Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

Chemical Property:

Density:1.448g/cm³
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:365.10209710
Heavy Atom Count:24
Complexity:542

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)NC1=C(C=C(C=N1)C(F)(F)F)NC(=O)C2CCCCC2

Technology Process of Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

There total 4 articles about Cyclohexanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2719-27-9
cyclohexanylcarbonyl chloride

: 141284-81-3
N-(3-amino-5-trifluoromethyl-pyridin-2-yl)-methanesulfonamide

: 141283-52-5
N-(2-methylsulfonylamino-5-trifluoromethyl-pyridin-3-yl)cyclohexanecarboxamide

Guidance literature:: In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.43.1696

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 141283-52-5
N-(2-methylsulfonylamino-5-trifluoromethyl-pyridin-3-yl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylsulfoxide / 7 h / 110 - 120 °C

2: 94percent aq. HNO₃ / acetic acid / 6 h / 105 - 110 °C

3: Fe, CH₃COOH / 1 h / 65 °C

4: 79 percent / tetrahydrofuran / Ambient temperature

With nitric acid; iron; potassium carbonate; acetic acid; In tetrahydrofuran; acetic acid; dimethyl sulfoxide;
DOI:10.1248/cpb.43.1696

Reference yield:

: 141284-83-5
N-[5-(Trifluoromethyl)pyridin-2-yl]methanesulfonamide

: 141283-52-5
N-(2-methylsulfonylamino-5-trifluoromethyl-pyridin-3-yl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94percent aq. HNO₃ / acetic acid / 6 h / 105 - 110 °C

2: Fe, CH₃COOH / 1 h / 65 °C

3: 79 percent / tetrahydrofuran / Ambient temperature

With nitric acid; iron; acetic acid; In tetrahydrofuran; acetic acid;
DOI:10.1248/cpb.43.1696