Technology Process of 3-cyclohexyl-3-(pyrimidin-2-ylsulfanyl)-propionic acid
There total 2 articles about 3-cyclohexyl-3-(pyrimidin-2-ylsulfanyl)-propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-sulfanylpyrimidine;
With
cesium fluoride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
(+/-)-4-cyclohexyloxetan-2-one;
In
N,N-dimethyl-formamide;
at 30 ℃;
for 1h;
DOI:10.1055/s-2001-12311
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: BF3*OEt2 / CH2Cl2
1.2: H2O / CH2Cl2 / 20 °C
1.3: KF*2H2O / acetonitrile
2.1: CsF / dimethylformamide / 0.17 h / 20 °C
2.2: dimethylformamide / 1 h / 30 °C
With
boron trifluoride diethyl etherate; cesium fluoride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-12311
- Guidance literature:
-
3-cyclohexyl-3-(pyrimidin-2-ylsulfanyl)-propionic acid;
With
hydroxylamine Wang resin; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl acetamide;
at 20 ℃;
for 2h;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
for 4h;
With
trifluoroacetic acid;
In
dichloromethane;
for 3h;
DOI:10.1055/s-2001-12311
