(S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid
• CAS No.: 117170-12-4
• Molecular Formula: C₂HF₃O₂*C₂₇H₃₉N₅O₈
• Molecular Weight: 675.659
• Mol file: 117170-12-4.mol

Synonyms:

Chemical Property of (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid

There total 5 articles about (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid (117170-12-4)

Guidance literature:

Multi-step reaction with 4 steps

2: 75 percent / NaOH / aq. propan-2-ol / 2 h / 20 °C

3: 77 percent / DCC / dimethylformamide / 1 h / -20 °C

4: 0.2 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt (16948-04-2,76477-42-4) → (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid (117170-12-4)

Guidance literature:

Multi-step reaction with 4 steps

2: 75 percent / NaOH / aq. propan-2-ol / 2 h / 20 °C

3: 77 percent / DCC / dimethylformamide / 1 h / -20 °C

4: 0.2 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysyl-alanyl-leucine methyl ester (117139-98-7) → (S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; compound with trifluoro-acetic acid (117170-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NaOH / aq. propan-2-ol / 2 h / 20 °C

2: 77 percent / DCC / dimethylformamide / 1 h / -20 °C

3: 0.2 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

(S)-2-[(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-propionylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

trifluoroacetic acid

methyl (L)-leucinate hydrochloride

N^α-tert-butyloxycarbonyl-N^ε-benzyloxycarbonyllysine dicyclohexylammonium salt