Technology Process of (Sp)-thymidylyl(3',5')thymidylyl methanephosphonate
There total 8 articles about (Sp)-thymidylyl(3',5')thymidylyl methanephosphonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) pyridine, 2) pyridine / 1) 0.5 h, 2) 1 h
2: 1) t-BuMgCl / 1) THF, 2) a) THF, 1 h, b) DMF, 20 h
With
pyridine; tert-butylmagnesium chloride;
DOI:10.1016/0040-4039(91)80465-I
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) pyridine, 2) pyridine / 1) 0.5 h, 2) 1 h
2: 1) t-BuMgCl / 1) THF, 2) a) THF, 1 h, b) DMF, 20 h
With
pyridine; tert-butylmagnesium chloride;
DOI:10.1016/0040-4039(91)80465-I
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / 1 h / Ambient temperature
2: t-butylmagnesium chloride / tetrahydrofuran; dimethylformamide / 21 h / Ambient temperature
With
tert-butylmagnesium chloride;
In
tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)96773-X
